dinucleotide repeat การใช้

• Mononucleotide and dinucleotide repeats should be avoided, as loop formation can occur and contribute to mishybridization.
• When exactly two nucleotides are repeated, it is called a " dinucleotide repeat " ( for example : ACACACAC & ).
• The most common microsatellite in humans is a dinucleotide repeat of the nucleotides A, which occurs tens of thousands of times across the genome.
• Repeated sequences of fewer than ten nucleotides ( e . g . the dinucleotide repeat ( AC ) n ) are termed microsatellite sequences.
• Three polymorphic repetitive sequences have been found in humans in the 5 flanking region : RS3, RS1, and a ( GT ) 25 dinucleotide repeat.
• This particular marker in the 5-alpha reductase gene, called a " TA dinucleotide repeat, " was found exclusively in black men, although not all black men.
• There are two principal families of VNTRs : unstable-dinucleotide repeats may vary from one tissue to another within an individual, while trinucleotide repeats have been found to vary from one generation to another ( see Huntington's disease ).
• However, several allelic dinucleotide repeat TA to the promoter region, resulting in A ( TA 7 ) TAA, which is called " UGT1A1 * 28 "; this common variant accounts for about 40 % of alleles in some populations, but is seen less often, around 3 % of alleles, in Southeast and East Asian people and Pacific Islanders.